News

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April 29, 2015
NEW PUBLICATION

HCoV-HKU1 Spike protein usues O-acetylated sialic acid as an attachment receptor determinant and emplys HE protein as a receptor-destroying enzyme.

Dec 2014
NEW PUBLICATION

Effects of human anti-spike protein receptor binding domain antibodies on SARS coronavirus neutralization escape and fitness.

June 26, 2014
NEW PUBLICATION

Prolonged expression of an anti-HIV-1 gp120 minibody to the female rhesus macaque lower genital tract by AAV gene transfer.


Announcements

Launch of Humanized Mouse Program

The Marasco Lab Humanized Mouse Program is open to the research community
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www.humouse.org

Project Highlight:
Emerging Infectious Disease: Broadly Neutralizing Antibody Responses (BnAb) to the Influenza Viruses

 

Molecular Signatures of Hemagglutinin Stem-Directed Heterosubtypic Human Neutralizing Antibodies Against Influenza A Viruses

  1. Molecular signatures occur in the VH domain of anti-influenza stem Abs.
  2. Rare VH-segment signatures occur in non-classical somatic hypermutation positions.
  3. Anti-influenza stem BnAbs can be generated with as few as one VH substitutions.
  4. Distinctive CDR-H2 substitutions facilitate HA binding of anchor residues.

Left - The location of F10 binding on the HA is shown with HA1 colored in salmon and HA2 colored in grey.  Right panel – The location of contact CDR residues. In light green is the HA2 fusion peptide from Trp212-to-Val182.