News

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April 30, 2013
Marasco speaking at PEGS Conference, Boston, MA

April 11-13, 2013
Marasco to participate at the Vatican Adult Stem Cell Conf.

Feb 11, 2013
Marasco appointed Principal Faculty at Harvard Stem Cell Institute

Jan  22, 2013
In the Media: Universal Flu Vaccine Update

Dec 2012
Marasco appointed full professor

Announcements

Launch of Humanized Mouse Program

The Marasco Lab Humanized Mouse Program is open to the research community
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www.humouse.org

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Project Highlight: Cancer Immunotherapy: Cutaneous T-Cell Lymphoma (CTCL)

Human anti-CCR4+ monoclonal antibody mAb2-3 has multifunctional roles.

  1. Blocks CCR4+ regulatory T cell (Treg) chemotactic migration to the tumor
  2. Blocks Treg suppression of tumor localized effector T cells (Teff)
  3. Promotes CCR4+ Teff activation and proliferation
  4. Kills CTCL tumor cells by antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC)